Protein Details: Aquaporin-9

Protein ID

ICDB_Pro_0212

Protein Name

Aquaporin-9

Gene Name

AQP9; SSC1

Organism

Homo sapiens (Human)

Length

295 amino acids

AlphaFoldDB

AF-O43315-F1-model_v4.pdb

Function

Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small;non-charged solutes including carbamides;polyols;purines;and pyrimidines.

Sequence

MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKTEQSEDKPEKYELSVIM

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Malignant Peritoneal Solitary Fibrous Tumor and Endocarditis

Location

Highly expressed in peripheral leukocytes. Also expressed in liver;lung;and spleen.

DOI ID

10.1006/bbrc.1998.8252; 10.1152/ajprenal.1999.277.5.f685; 10.1038/nature04601; 10.1101/gr.2596504; 10.1038/s41467-018-07176-z

RefSeq

NP_066190.2